… studies, whereupon CXCR3, CXCR4, and ACKR3 small-molecule ligands were competed
for binding against the radiolabeled agonist. Interestingly, the chemokine ligands CXCL11 …

… ligands and their pharmacological characterization for modulation of chemokine receptors.
Ligands … Thus, the noncompetitive nature of these small molecule antagonists at CXCR3 and …

… SIGNIFICANCE STATEMENT We are interested in the signaling produced by the G protein
coupled receptor atypical chemokine receptor 3 (ACKR3), which signals atypically. In this …

… Photochemical and pharmacological characterisation of ligands 3a-l were performed in …
Ability of inhibition of agonist-induced β-arrestin2 recruitment to indicated chemokine receptors …

… bind to chemokines. The development of drugs acting on chemokine receptors has been
challenging.At present, two small-molecule drugs targeting chemokine receptors have been …

… For instance, CCR1, CCR2, CCR5, and CXCR3 are all involved in the … of small-molecule
binding to chemokine receptors offers a promising strategy for virtual screening and drug …

… However, despite significant investments by the pharmaceutical industries, only one small-molecule
antagonist (AMG 487) reached the clinical phase. (4,5) Unfortunately, its …

… For example, chemokine agonists for CCR3 and CXCR3 act … to fine tune their pharmacological
properties at the receptor, and … to provide detailed pharmacological characterisation of …

… chemokine receptor 4 (CXCR4), for which it is the sole ligand, while CXCL11 is also interacting
with chemokine receptor CXCR3… potent and drug-like small molecule agonist was shown …

… The structures of CXCR3 coupled with small molecule agonists PS372424 and VUF11222 …
of small molecule agonists with chemokines targeting typical chemokine receptors. These two …